Verapamil Hydrochloride

Treats supraventricular tachyarrhythmias. Sold as Isoptin, Calan, Verapamil Hydrochloride, Calan Sr, Verelan and 2 more. Every FDA application for this active ingredient: 9 branded and 68 generic.

As of Nov 15, 2026, FDA lists 77 applications for Verapamil Hydrochloride (sold as Isoptin, Calan, Verapamil Hydrochloride and others), first approved Aug 12, 1981, with 5 new uses approved and 0 published complete response letters.

First approved: Aug 12, 1981
Applications: 77
New uses approved: 5
Complete response letters: 0
Medicare spending, 2025: $79.4M

Medicare Spending

CMS Part D and Part B, 2025, before manufacturer rebates; matched by generic name


Verapamil SR	Part D	$31.3M	+2%	78,447
Verapamil ER	Part D	$28.1M	-11%	265,394
Verapamil ER PM	Part D	$17.1M	-12%	11,455
Verapamil HCl	Part D	$2.9M	+3%	57,860
Verelan PM	Part D	$17K	-84%	20

What Pharmacies Pay

Median price per unit across package codes in CMS's weekly NADAC survey, Nov 11, 2026, before rebates; see every drug's price change

VERAPAMIL 120 MG TABLET: $0.086 per unitGeneric · +4% in a year
VERAPAMIL 40 MG TABLET: $0.112 per unitGeneric · -14% in a year
VERAPAMIL 80 MG TABLET: $0.072 per unitGeneric · +1% in a year
VERAPAMIL ER 120 MG CAPSULE: $2.92 per unitGeneric · +139% in a year
VERAPAMIL ER 120 MG TABLET: $0.202 per unitGeneric · -5% in a year
VERAPAMIL ER 180 MG CAPSULE: $2.83 per unitGeneric · +79% in a year
VERAPAMIL ER 180 MG TABLET: $0.194 per unitGeneric · +9% in a year
VERAPAMIL ER 240 MG CAPSULE: $3.43 per unitGeneric · +122% in a year
VERAPAMIL ER 240 MG TABLET: $0.192 per unitGeneric · +15% in a year
VERAPAMIL SR 120 MG CAPSULE: $2.92 per unitGeneric · +139% in a year
VERAPAMIL SR 180 MG CAPSULE: $2.83 per unitGeneric · +79% in a year
VERAPAMIL SR 240 MG CAPSULE: $3.43 per unitGeneric · +122% in a year

Approvals in Japan (PMDA)

PMDA's English list since 2008, matched by ingredient; see all Japanese approvals

VasolanA drug with a new additional dosage indicated for the treatment of tachyarrhythmia in pediatric patients (paroxysmal supraventricular tachycardia,… · Eisai Co., Ltd. · May 20, 2011
VasolanA drug with a new additional indication and a new dosage for the treatment of tachyarrhythmia in pediatric patients (atrial fibrillation, atrial flutter,… · Eisai Co., Ltd. · May 20, 2011

Clinical Trials

5 open or ongoing studies name this ingredient as an intervention, including as a comparator; newest first. See all


Comparing Two Heart Medicines for Fast, Irregular Heartbeat (Atrial Fibrillation)Atrial Fibrillation (AF), Atrial Fibrillation With Rapid Ventricular Response · Muhammad Ali Javed	Phase 4	Not yet recruiting	Jul 15, 2026
Verapamil Effect in Cystic Fibrosis-related DysglycemiaCystic Fibrosis Related Diabetes, Cystic Fibrosis (CF) · Rhode Island Hospital	Phase 2	Not yet recruiting	Jul 7, 2026
Characterization of the Synergistic Antibacterial Effect of Verapamil on Bacterial Isolates From Cancer PatientsMulti Drug Resistant Organisms, Antibiotic Resistance · Assiut University	—	Not yet recruiting	Apr 1, 2026
Treatment Effects of Bisoprolol and Verapamil in Symptomatic Patients With Non-obstructive Hypertrophic CardiomyopathyNon-obstructive Hypertrophic Cardiomyopathy · Morten Steen Kvistholm Jensen	Phase 4	Recruiting	Oct 6, 2022
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed InfantsLactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI · Duke University	—	Recruiting	Apr 27, 2018

Applications

NDAs, BLAs and generic ANDAs for this ingredient, oldest first; each opens its full history


Aug 12, 1981	IsoptinNDA 18485 · New molecular entity	Mt Adams	9	Discontinued
Mar 8, 1982	IsoptinNDA 18593 · New dosage form	Mt Adams	11	Discontinued
Mar 30, 1984	Verapamil HydrochlorideNDA 18925 · New formulation or manufacturer	Exela Pharma	10	Marketed
Mar 30, 1984	CalanNDA 19038 · New formulation or manufacturer	Gd Searle LLC	4	Discontinued
Sep 10, 1984	CalanNDA 18817 · New formulation or manufacturer	Pfizer	27	Discontinued
Nov 12, 1985	Verapamil HydrochlorideANDA 70617	Luitpold	14	Discontinued
Nov 12, 1985	Verapamil HydrochlorideANDA 70225	Luitpold	12	Discontinued
Dec 16, 1985	Verapamil HydrochlorideANDA 70451	Intl Medication	7	Discontinued
Aug 20, 1986	Verapamil HydrochlorideANDA 70340	Warner Chilcott	0	Discontinued
Aug 20, 1986	Verapamil HydrochlorideANDA 70341	Warner Chilcott	0	Discontinued
Sep 23, 1986	Verapamil HydrochlorideANDA 70468	Actavis Elizabeth	30	Discontinued
Sep 23, 1986	Verapamil HydrochlorideANDA 70482	Mutual Pharm	15	Discontinued
Sep 23, 1986	Verapamil HydrochlorideANDA 70483	Mutual Pharm	16	Discontinued
Sep 23, 1986	Verapamil HydrochlorideANDA 70855	Watson Labs	12	Discontinued
Sep 23, 1986	Verapamil HydrochlorideANDA 70856	Watson Labs	11	Discontinued
Sep 23, 1986	Verapamil HydrochlorideANDA 71019	Actavis Elizabeth	28	Discontinued
Oct 1, 1986	Verapamil HydrochlorideANDA 70994	Watson Labs	22	Marketed
Oct 1, 1986	Verapamil HydrochlorideANDA 70995	Watson Labs	22	Marketed
Oct 1, 1986	Verapamil HydrochlorideANDA 71366	Watson Labs	16	Discontinued
Oct 1, 1986	Verapamil HydrochlorideANDA 71367	Watson Labs	16	Discontinued
Dec 16, 1986	Calan SrNDA 19152 · New dosage form	Pfizer	37	Discontinued
Feb 2, 1987	Verapamil HydrochlorideANDA 70577	Hospira	8	Discontinued
May 6, 1987	Verapamil HydrochlorideANDA 70739	Hospira	4	Discontinued
May 6, 1987	Verapamil HydrochlorideANDA 70740	Hospira	3	Discontinued
May 6, 1987	Verapamil HydrochlorideANDA 70737	Hospira	13	Marketed
May 6, 1987	Verapamil HydrochlorideANDA 70738	Hospira	8	Marketed
Jan 13, 1988	Verapamil HydrochlorideANDA 71489	Sun Pharm Industries	14	Discontinued
Apr 5, 1988	Verapamil HydrochlorideANDA 71881	Heritage	8	Marketed
May 25, 1988	Verapamil HydrochlorideANDA 71423	Chartwell Rx	11	Discontinued
May 25, 1988	Verapamil HydrochlorideANDA 71424	Chartwell Rx	11	Discontinued
Jan 26, 1989	Verapamil HydrochlorideANDA 72124	Pliva	7	Discontinued
Jan 26, 1989	Verapamil HydrochlorideANDA 72125	Pliva	7	Discontinued
Feb 15, 1989	Verapamil HydrochlorideANDA 71483	Rising	14	Discontinued
May 29, 1990	VerelanNDA 19614 · New dosage form	Azurity	34	Marketed
Jul 31, 1992	Verapamil HydrochlorideANDA 73168	Chartwell Rx	7	Discontinued
Jul 31, 1992	Verapamil HydrochlorideANDA 73568	Ivax Sub Teva Pharms	44	Discontinued
Feb 26, 1993	Verapamil HydrochlorideANDA 72233	Marsam Pharms LLC	1	Discontinued
Jun 29, 1993	Verapamil HydrochlorideANDA 72923	Watson Labs	7	Discontinued
Jun 29, 1993	Verapamil HydrochlorideANDA 72924	Watson Labs	11	Marketed
Sep 27, 1993	Verapamil HydrochlorideANDA 73485	Marsam Pharms LLC	1	Discontinued
Jan 31, 1994	Verapamil HydrochlorideANDA 74330	Ivax Sub Teva Pharms	23	Discontinued
Jul 28, 1995	Verapamil HydrochlorideANDA 72888	Bedford	0	Discontinued
Feb 23, 1996	Verapamil HydrochlorideANDA 72751	Pliva	2	Discontinued
Feb 26, 1996	Covera-HsNDA 20552 · New formulation or manufacturer	Pfizer	7	Discontinued
Mar 1, 1996	Verapamil HydrochlorideANDA 72922	Pliva	1	Discontinued
Mar 23, 1996	Verapamil HydrochlorideANDA 74587	Rising	27	Discontinued
Oct 20, 1998	Verapamil HydrochlorideANDA 75136	Hospira	2	Discontinued
Nov 25, 1998	Verelan PmNDA 20943 · New dosage form	Azurity	15	Marketed
Apr 20, 1999	Verapamil HydrochlorideANDA 75138	Mylan	9	Marketed
May 25, 1999	Verapamil HydrochlorideANDA 75072	Strides Pharma Intl	6	Marketed
Aug 9, 2007	Verapamil HydrochlorideANDA 78306	Rising	6	Discontinued
Sep 17, 2009	Verapamil HydrochlorideANDA 78906	Glenmark Pharms Ltd	6	Marketed
Aug 3, 2011	Verapamil HydrochlorideANDA 90700	Glenmark Pharms Ltd	5	Marketed
Dec 30, 2011	Verapamil HydrochlorideANDA 90529	Sun Pharm Inds Inc	2	Discontinued
Apr 20, 2012	Verapamil HydrochlorideANDA 200878	Apotex Corp	1	Discontinued
May 5, 2017	Verapamil HydrochlorideANDA 206173	Cadila Pharms Ltd	2	Marketed
Jun 18, 2018	Verapamil HydrochlorideANDA 211015	Somerset Theraps LLC	4	Marketed
Jun 18, 2018	Verapamil HydrochlorideANDA 211035	Somerset	2	Marketed
Jul 13, 2018	Verapamil HydrochlorideANDA 210994	Amneal	1	Discontinued
Dec 28, 2018	Verapamil HydrochlorideANDA 211370	Micro Labs	1	Marketed
Mar 17, 2020	Verapamil HydrochlorideANDA 213352	Nephron	0	Marketed
Mar 25, 2020	Verapamil HydrochlorideANDA 213232	Caplin	0	Marketed
Jul 6, 2020	Verapamil HydrochlorideANDA 212965	Eugia Pharma	0	Marketed
Oct 15, 2020	Verapamil HydrochlorideANDA 214215	Zydus Pharms	0	Marketed
Oct 15, 2020	Verapamil HydrochlorideANDA 214361	Gland	0	Marketed
Mar 17, 2022	Verapamil HydrochlorideANDA 215829	Heritage	0	Marketed
Jun 15, 2022	Verapamil HydrochlorideANDA 214653	Mankind Pharma	0	Marketed
Apr 23, 2024	Verapamil HydrochlorideANDA 216471	Fresenius Kabi USA	0	Marketed
Nov 13, 2025	Verapamil HydrochlorideANDA 218218	Aspiro	0	Marketed
Nov 24, 2025	Verapamil HydrochlorideANDA 219252	Zydus Lifesciences	0	Marketed
Jul 22, 2026	Verapamil HydrochlorideANDA 220076	Knack	0	Marketed
—	Verapamil HydrochlorideANDA 70697	Smith And Nephew	0	Discontinued
—	Verapamil HydrochlorideANDA 70348	Abraxis Pharm	0	Discontinued
—	Verapamil HclANDA 70672	Quad Pharms	0	Discontinued
—	Verapamil HydrochlorideANDA 70695	Solopak	0	Discontinued
—	Verapamil HydrochlorideANDA 70696	Smith And Nephew	0	Discontinued
—	Verapamil HydrochlorideANDA 72799	Watson Labs	0	Discontinued

Show all 77

Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA