Logos are each company's own site icon, matched by name through Wikidata.Company names and logos identify the companies in public FDA and registry records and do not imply endorsement.
Treats acne vulgaris. Sold as Retin-A, Renova, Avita, Vesanoid, Retin-A Micro and 3 more. Every FDA application for this active ingredient: 14 branded and 33 generic.
As of Nov 15, 2026, FDA lists 47 applications for Tretinoin (sold as Retin-A, Renova, Avita and others), first approved Oct 20, 1971, with 3 new uses approved and 0 published complete response letters.
First approved: Oct 20, 1971
Applications: 47
New uses approved: 3
Complete response letters: 0
Medicare spending, 2025: $23.3M
Safety program: REMS
Medicare Spending
CMS Part D and Part B, 2025, before manufacturer rebates; matched by generic name
Tretinoin
Part D
$22.3M
+5%
143,667
Retin-A
Part D
$938K
-7%
14,703
Altreno
Part D
$87K
-6%
565
Atralin
Part D
$0K
-100%
0
What Pharmacies Pay
Median price per unit across package codes in CMS's weekly NADAC survey, Nov 11, 2026, before rebates; see every drug's price change
TRETINOIN 0.01% GEL: $2.28 per GMGeneric · -17% in a year
TRETINOIN 0.025% CREAM: $0.508 per GMGeneric · -49% in a year
TRETINOIN 0.025% GEL: $2.61 per GMGeneric · -7% in a year
TRETINOIN 0.05% CREAM: $1.40 per GMGeneric · -3% in a year
TRETINOIN 0.05% GEL: $4.01 per GMGeneric · -7% in a year
TRETINOIN 0.1% CREAM: $0.872 per GMGeneric · -20% in a year
TRETINOIN 10 MG CAPSULE: $8.53 per unitGeneric · -32% in a year
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient.Drugs@FDA
Mylan Pharms Inc
Wockhardt
Allergan
Sun Pharma Canada
Zydus Lifesciences
Alembic