Prazosin Hydrochloride

Treats hypertension. Sold as Minipress, Minipress Xl. Every FDA application for this active ingredient: 2 branded and 27 generic.

As of Nov 15, 2026, FDA lists 29 applications for Prazosin Hydrochloride (sold as Minipress, Minipress Xl), first approved Jun 23, 1976, with 0 new uses approved and 0 published complete response letters.

First approved: Jun 23, 1976
Applications: 29
New uses approved: 0
Complete response letters: 0
Medicare spending, 2025: $25.4M

Medicare Spending

CMS Part D and Part B, 2025, before manufacturer rebates; matched by generic name

Product	Part	Spending, 2025	Change	Beneficiaries
Prazosin HCl	Part D	$25.4M	+1%	234,011

What Pharmacies Pay

Median price per unit across package codes in CMS's weekly NADAC survey, Nov 11, 2026, before rebates; see every drug's price change

PRAZOSIN 1 MG CAPSULE: $0.084 per unitGeneric · -19% in a year
PRAZOSIN 2 MG CAPSULE: $0.083 per unitGeneric · -10% in a year
PRAZOSIN 5 MG CAPSULE: $0.140 per unitGeneric · -4% in a year

Clinical Trials

5 open or ongoing studies name this ingredient as an intervention, including as a comparator; newest first. See all


Assessing Trauma-related Links Between Affective and Metabolic SystemsPosttraumatic Stress Disorder, Metabolic Syndrome · VA Office of Research and Development	Phase 4	Not yet recruiting	Oct 7, 2026
Brain Blood Vessel Responses to Changes in Blood FlowMagnetic Resonance Imaging, Cerebrovascular Circulation · University of Wisconsin, Madison	Phase 2	Recruiting	Oct 8, 2024
Brain Blood Vessel Responses to Changes in Blood Flow: Younger CohortMagnetic Resonance Imaging, Cerebrovascular Circulation · University of Wisconsin, Madison	Phase 2	Recruiting	Oct 8, 2024
Alpha-1 Blockade for Alcohol Use Disorder (AUD)Alcohol Use Disorder (AUD) · Brown University	Phase 2	Active, not recruiting	Oct 23, 2019
Predicting Responses to PTSD Treatment With Iris and Cardiovascular TestsPosttraumatic Stress Disorder · VA Office of Research and Development	Phase 3	Active, not recruiting	May 29, 2018

Applications

NDAs, BLAs and generic ANDAs for this ingredient, oldest first; each opens its full history


Jun 23, 1976	MinipressNDA 17442 · New molecular entity	Pfizer	34	Marketed
Sep 12, 1988	Prazosin HydrochlorideANDA 71745	Teva Pharms	12	Marketed
Sep 12, 1988	Prazosin HydrochlorideANDA 71994	Ivax Sub Teva Pharms	12	Marketed
Sep 12, 1988	Prazosin HydrochlorideANDA 71995	Teva Pharms	13	Marketed
Jan 11, 1989	Prazosin HydrochlorideANDA 72333	Watson Labs	5	Discontinued
Jan 11, 1989	Prazosin HydrochlorideANDA 72352	Watson Labs	5	Discontinued
Jan 11, 1989	Prazosin HydrochlorideANDA 72609	Watson Labs	5	Discontinued
Feb 28, 1989	Prazosin HydrochlorideANDA 72573	Mylan	7	Marketed
Feb 28, 1989	Prazosin HydrochlorideANDA 72574	Mylan	7	Marketed
Feb 28, 1989	Prazosin HydrochlorideANDA 72575	Mylan	10	Marketed
Mar 15, 1989	Prazosin HydrochlorideANDA 72705	Dava Pharms Inc	8	Discontinued
Mar 15, 1989	Prazosin HydrochlorideANDA 72706	Dava Pharms Inc	8	Discontinued
Mar 15, 1989	Prazosin HydrochlorideANDA 72707	Dava Pharms Inc	9	Discontinued
Apr 10, 1989	Prazosin HydrochlorideANDA 72577	Ani Pharms	2	Discontinued
Jan 29, 1992	Minipress XlNDA 19775 · New dosage form	Pfizer	2	Discontinued
Oct 3, 2018	Prazosin HydrochlorideANDA 210971	Novitium Pharma	0	Marketed
Dec 23, 2021	Prazosin HydrochlorideANDA 214608	Granules	0	Marketed
Oct 21, 2022	Prazosin HydrochlorideANDA 213406	Appco	0	Marketed
Dec 30, 2022	Prazosin HydrochlorideANDA 215697	Mankind Pharma	0	Marketed
Mar 6, 2023	Prazosin HydrochlorideANDA 217268	Alembic	0	Marketed
Mar 31, 2023	Prazosin HydrochlorideANDA 213052	Aurobindo Pharma Ltd	0	Marketed
Jan 3, 2024	Prazosin HydrochlorideANDA 214083	Lannett Co Inc	0	Discontinued
Sep 17, 2024	Prazosin HydrochlorideANDA 216727	Msn	0	Marketed
—	Prazosin HydrochlorideANDA 72782	Am Therap	0	Discontinued
—	Prazosin HydrochlorideANDA 72783	Am Therap	0	Discontinued
—	Prazosin HydrochlorideANDA 72784	Am Therap	0	Discontinued
—	Prazosin HydrochlorideANDA 72921	Purepac Pharm	0	Discontinued
—	Prazosin HydrochlorideANDA 72991	Purepac Pharm	0	Discontinued
—	Prazosin HydrochlorideANDA 72992	Purepac Pharm	0	Discontinued

Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA