Sold as Pipracil. Every FDA application for this active ingredient: 1 branded and 3 generic.
As of Nov 15, 2026, FDA lists 4 applications for Piperacillin Sodium (sold as Pipracil), first approved Dec 29, 1981, with 2 new uses approved and 0 published complete response letters.
| Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated AppendicitisAppendicitis Perforated, Appendectomy, Laparoscopic · McMaster Children's Hospital | Phase 3 | Not yet recruiting | Oct 9, 2026 |
| Tissue Penetration of Antibiotics in CriTically Ill ChildrenPediatric Critical Illness, Critical Illness · University Hospital, Ghent | — | Recruiting | Sep 16, 2026 |
| Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled TrialHospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP) · The University of Queensland | Not applicable | Not yet recruiting | Sep 15, 2026 |
| Differentiating True Nephrotoxicity From Pseudo-nephrotoxicity: A Prospective Comparative Study of Vancomycin Plus Piperacillin-Tazobactam vs. Meropenem Using Serum Creatinine and Cystatin-CNephrotoxicity, Bacterial Infections · King Faisal Specialist Hospital & Research Center | — | Recruiting | Sep 14, 2026 |
| Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver TransplantationLiver Transplant, Carbapenem-resistant Enterobacterales · IRCCS Azienda Ospedaliero-Universitaria di Bologna | Phase 3 | Not yet recruiting | Aug 12, 2026 |
| INterest of the Negative Predictive Value of Integrons in the reduCtion of Large Broad-spectrum anTibiotics Consumption for Urinary Tract infectionSDrug Resistance, Microbial, Biomarkers · University Hospital, Limoges | Not applicable | Recruiting | Jun 30, 2026 |
| Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant SettingsHepatobiliary Surgery, Prophylactic Antibiotics · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Not applicable | Recruiting | Jun 2, 2026 |
| Continuous Antibiotic Infusion In ChildrenInfection · Tampere University Hospital | Phase 3 | Recruiting | May 8, 2026 |
| Dec 29, 1981 | PipracilNDA 50545 · New molecular entity | Wyeth Pharms Inc | 39 | Discontinued |
| Oct 13, 1987 | PipracilANDA 62750 | Wyeth Pharms Inc | 13 | Discontinued |
| Nov 14, 2003 | PiperacillinANDA 65114 | Acs Dobfar Spa | 5 | Discontinued |
| Jul 12, 2004 | PiperacillinANDA 65157 | Acs Dobfar Spa | 5 | Discontinued |
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA
