Phentermine Hydrochloride

Sold as Wilpo, Fastin, Suprenza. Every FDA application for this active ingredient: 3 branded and 97 generic.

As of Nov 15, 2026, FDA lists 100 applications for Phentermine Hydrochloride (sold as Wilpo, Fastin, Suprenza), first approved Aug 14, 1973, with 0 new uses approved and 0 published complete response letters.

First approved: Aug 14, 1973
Applications: 100
New uses approved: 0
Complete response letters: 0
Medicare spending, 2025: $14K

Medicare Spending

CMS Part D and Part B, 2025, before manufacturer rebates; matched by generic name

Product	Part	Spending, 2025	Change	Beneficiaries
Phentermine HCl	Part D	$14K	+32%	518

What Pharmacies Pay

Median price per unit across package codes in CMS's weekly NADAC survey, Nov 11, 2026, before rebates; see every drug's price change

PHENTERMINE 15 MG CAPSULE: $0.103 per unitGeneric · +24% in a year
PHENTERMINE 30 MG CAPSULE: $0.129 per unitGeneric · +35% in a year
PHENTERMINE 37.5 MG CAPSULE: $0.105 per unitGeneric · +25% in a year
PHENTERMINE 37.5 MG TABLET: $0.074 per unitGeneric · +10% in a year
PHENTERMINE 8 MG TABLET: $0.628 per unitGeneric · new this year

Clinical Trials

16 open or ongoing studies name this ingredient as an intervention, including as a comparator; newest first. See all


Comparing Different Medication Regimens to Maintaining Weight Loss Among Adults With Obesity Using GLP-1sObesity & Overweight, Cardiometabolic Health Indicators · Jing Luo	Phase 4	Not yet recruiting	Sep 21, 2026
Obesity Treatment With Phentermine-Topiramate ER in AYA Surviving Leukemia and LymphomaAcute Lymphoblastic Leukemia in Remission, Hodgkin Lymphoma in Remission · St. Jude Children's Research Hospital	Phase 2	Not yet recruiting	Aug 27, 2026
Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity PharmacotherapyObesity & Overweight · Phenomix Sciences	Not applicable	Not yet recruiting	Jul 27, 2026
Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1 Therapy DiscontinuationObesity · Massachusetts General Hospital	Phase 4	Not yet recruiting	Jul 27, 2026
Phentermine's Impact on Treatment in TeensChildhood Obesity · Russell McCulloh, MD	Phase 2	Recruiting	Dec 15, 2025
Individualized Pharmacological Approach to Obesity in Patients With Bipolar DisorderBipolar I Disorder, Bipolar II Disorder · Mayo Clinic	Phase 4	Recruiting	Oct 9, 2025
Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Real-world Settings (DASH-CKMH)Cardiovascular Kidney Metabolic Syndrome · Ohio State University	—	Active, not recruiting	Sep 23, 2025
Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver DiseaseLiver Cirrhoses, Portal Hypertension Related to Cirrhosis · The Cleveland Clinic	Phase 4	Recruiting	Jul 10, 2025

Applications

NDAs, BLAs and generic ANDAs for this ingredient, oldest first; each opens its full history


Aug 14, 1973	FastinNDA 17352 · New dosage form	Glaxosmithkline	15	Discontinued
Feb 24, 1976	ToraANDA 84035	Solvay	0	Discontinued
Jul 1, 1976	Phentermine HydrochlorideANDA 83923	Chartwell Rx	13	Discontinued
Mar 14, 1977	Phentermine HydrochlorideANDA 85319	Chartwell Rx	13	Discontinued
Apr 11, 1978	Phentermine HydrochlorideANDA 85553	Ivax Pharms	0	Discontinued
Apr 28, 1978	Phentermine HydrochlorideANDA 85671	Sandoz	1	Discontinued
Apr 28, 1978	Phentermine HydrochlorideANDA 85689	Sandoz	2	Discontinued
May 19, 1978	Phentermine HydrochlorideANDA 85739	Watson Labs	0	Discontinued
Dec 8, 1978	Phentermine HydrochlorideANDA 86329	Ivax Pharms	0	Discontinued
Mar 24, 1980	Ona-MastANDA 86260	Mast Mm	0	Discontinued
Sep 10, 1980	Phentermine HydrochlorideANDA 85411	Abc Holding	12	Discontinued
Sep 10, 1980	Phentermine HydrochlorideANDA 86732	Chartwell Rx	14	Discontinued
Sep 10, 1980	Phentermine HydrochlorideANDA 85417	Chartwell Rx	14	Discontinued
Sep 10, 1980	Phentermine HydrochlorideANDA 87226	Camall	12	Discontinued
Sep 10, 1980	Phentermine HydrochlorideANDA 86735	Camall	11	Discontinued
Sep 10, 1980	Phentermine HydrochlorideANDA 87215	Chartwell Rx	14	Discontinued
Oct 22, 1980	Adipex-PANDA 85128	Teva	59	Marketed
Apr 3, 1981	Ona-MastANDA 86516	Mast Mm	0	Discontinued
Apr 14, 1981	Obestin-30ANDA 87144	Ferndale Labs	0	Discontinued
Jun 12, 1981	Phentermine HydrochlorideANDA 87190	Sandoz	22	Marketed
Jun 12, 1981	Phentermine HydrochlorideANDA 87223	Sandoz	15	Discontinued
Jun 12, 1981	Phentermine HydrochlorideANDA 87208	Sandoz	13	Discontinued
Jun 12, 1981	Phentermine HydrochlorideANDA 87301	Sandoz	20	Discontinued
Sep 17, 1981	Ona-MastANDA 86511	Mast Mm	0	Discontinued
Mar 18, 1982	Oby-TrimANDA 87764	Shire Richwood	4	Discontinued
Apr 9, 1982	Phentermine HydrochlorideANDA 84487	Upsher Smith Labs	11	Discontinued
Dec 6, 1982	Phentermine HydrochlorideANDA 87805	Chartwell Rx	15	Discontinued
Feb 3, 1983	Phentermine HydrochlorideANDA 87022	Lannett	9	Discontinued
Jul 20, 1983	Phentermine HydrochlorideANDA 86945	Sandoz	19	Marketed
Aug 2, 1983	Adipex-PANDA 88023	Teva	34	Discontinued
Oct 14, 1983	Phentermine HydrochlorideANDA 87930	Chartwell Rx	10	Discontinued
Oct 19, 1983	Phentermine HydrochlorideANDA 88414	Sandoz	2	Discontinued
Dec 22, 1983	Phentermine HydrochlorideANDA 87915	Chartwell Rx	14	Discontinued
Dec 22, 1983	Phentermine HydrochlorideANDA 87918	Chartwell Rx	14	Discontinued
Mar 27, 1984	Phentermine HydrochlorideANDA 88430	Upsher Smith Labs	10	Discontinued
Apr 4, 1984	Phentermine HydrochlorideANDA 88596	Chartwell Rx	14	Discontinued
May 23, 1984	Phentermine HydrochlorideANDA 88576	Chartwell Rx	11	Discontinued
Jun 4, 1984	Phentermine HydrochlorideANDA 88611	Chartwell Rx	9	Discontinued
Jun 4, 1984	Phentermine HydrochlorideANDA 88610	Chartwell Rx	8	Discontinued
Aug 23, 1984	Phentermine HydrochlorideANDA 88625	Chartwell Rx	11	Discontinued
Mar 21, 1985	Phentermine HydrochlorideANDA 86740	Watson Labs	0	Discontinued
Apr 25, 1986	Phentermine HydrochlorideANDA 88948	Duramed Pharms Barr	2	Discontinued
Sep 28, 1987	Phentermine HydrochlorideANDA 88605	Sandoz Inc	11	Discontinued
Mar 7, 1997	Phentermine HydrochlorideANDA 40083	Tg United Inc	1	Discontinued
May 30, 1997	Phentermine HydrochlorideANDA 40190	Elite Labs Inc	6	Marketed
Jun 18, 1997	Phentermine HydrochlorideANDA 40227	Elite Labs Inc	5	Discontinued
Jun 19, 1997	Phentermine HydrochlorideANDA 40228	Elite Labs Inc	5	Discontinued
Nov 25, 1998	Phentermine HydrochlorideANDA 40276	Actavis Elizabeth	4	Discontinued
Aug 30, 2001	Phentermine HydrochlorideANDA 40402	Able	0	Discontinued
Aug 30, 2001	Phentermine HydrochlorideANDA 40403	Able	0	Discontinued
Aug 30, 2001	Phentermine HydrochlorideANDA 40427	Able	0	Discontinued
Jan 4, 2002	Phentermine HydrochlorideANDA 40377	Prinston	3	Marketed
Jan 14, 2003	Phentermine HydrochlorideANDA 40460	Elite Labs Inc	2	Discontinued
Jan 22, 2003	Phentermine HydrochlorideANDA 40448	Elite Labs Inc	1	Discontinued
Mar 13, 2003	Phentermine HydrochlorideANDA 40497	Able	0	Discontinued
Oct 23, 2003	Phentermine HydrochlorideANDA 40525	Sun Pharm Industries	4	Discontinued
Oct 23, 2003	Phentermine HydrochlorideANDA 40526	Sun Pharm Industries	4	Marketed
Oct 23, 2003	Phentermine HydrochlorideANDA 40527	Sun Pharm Industries	1	Discontinued
Apr 15, 2005	Phentermine HydrochlorideANDA 40555	Lannett	4	Discontinued
Aug 21, 2007	Phentermine HydrochlorideANDA 40790	Sun Pharm Inds Inc	2	Discontinued
Mar 21, 2008	Phentermine HydrochlorideANDA 40875	Kvk Tech	2	Marketed
Mar 31, 2008	Phentermine HydrochlorideANDA 40876	Kvk Tech	3	Marketed
Mar 31, 2008	Phentermine HydrochlorideANDA 40886	Kvk Tech	2	Marketed
Apr 24, 2008	Phentermine HydrochlorideANDA 40887	Kvk Tech	3	Marketed
Aug 31, 2009	Phentermine HydrochlorideANDA 90470	Barr	3	Discontinued
Mar 18, 2010	Phentermine HydrochlorideANDA 90591	Barr	3	Discontinued
Jul 16, 2010	Phentermine HydrochlorideANDA 91359	Lannett Co Inc	4	Discontinued
Jan 31, 2011	Phentermine HydrochlorideANDA 200272	Elite Labs	2	Marketed
Jul 20, 2011	Phentermine HydrochlorideANDA 201961	Lannett Co Inc	4	Discontinued
Mar 27, 2012	SuprenzaNDA 202088 · Efficacy (new indication or use)	Citius Pharms	6	Discontinued
Sep 21, 2012	Phentermine HydrochlorideANDA 91451	Ingenus Pharms LLC	2	Discontinued
Sep 28, 2012	Phentermine HydrochlorideANDA 202248	Elite Labs	2	Marketed
Feb 5, 2014	Phentermine HydrochlorideANDA 202846	Invagen Pharms	1	Discontinued
Feb 5, 2014	Phentermine HydrochlorideANDA 202942	Invagen Pharms	1	Discontinued
Feb 14, 2014	Phentermine HydrochlorideANDA 202858	Invagen Pharms	1	Discontinued
May 5, 2014	Phentermine HydrochlorideANDA 204414	Invagen Pharms	1	Discontinued
Aug 6, 2014	Phentermine HydrochlorideANDA 203068	Aurobindo Pharma Ltd	1	Marketed
Sep 25, 2014	Phentermine HydrochlorideANDA 205017	Nuvo Pharm	1	Marketed
Sep 25, 2014	Phentermine HydrochlorideANDA 205008	Nuvo Pharm	1	Marketed
Dec 5, 2014	Phentermine HydrochlorideANDA 205019	Nuvo Pharm	1	Marketed
Sep 12, 2016	LomairaANDA 203495	Avanthi Inc	0	Marketed
Nov 9, 2016	Phentermine HydrochlorideANDA 204318	Aurolife Pharma LLC	1	Marketed
Nov 18, 2016	Phentermine HydrochlorideANDA 206342	Puracap Labs Blu	1	Marketed
Mar 17, 2017	Phentermine HydrochlorideANDA 203436	Kvk Tech Inc	0	Marketed
Jun 28, 2017	Phentermine HydrochlorideANDA 204663	Zydus Pharms	0	Marketed
—	WilpoNDA 12737	Sandoz	0	Discontinued
—	Phentermine HydrochlorideANDA 83804	Usl Pharma	0	Discontinued
—	Phentermine HydrochlorideANDA 88614	Teva	0	Discontinued
—	Phentermine HydrochlorideANDA 86453	Vitarine	3	Discontinued
—	Phentermine HydrochlorideANDA 86456	Vitarine	3	Discontinued
—	Phentermine HydrochlorideANDA 86911	Teva	0	Discontinued
—	Phentermine HydrochlorideANDA 87126	Teva	0	Discontinued
—	Phentermine HydrochlorideANDA 87202	Vitarine	6	Discontinued
—	Phentermine HydrochlorideANDA 87235	Vitarine	1	Discontinued
—	Phentermine HydrochlorideANDA 87777	Teva	0	Discontinued
—	Phentermine HydrochlorideANDA 88612	Teva	0	Discontinued
—	Phentermine HydrochlorideANDA 88613	Teva	0	Discontinued
—	Phentermine HydrochlorideANDA 88797	Usl Pharma	0	Discontinued
—	Phentermine HydrochlorideANDA 88917	Usl Pharma	0	Discontinued
—	Phentermine HydrochlorideANDA 88910	Usl Pharma	0	Discontinued

Show all 100

Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA