Logos are each company's own site icon, matched by name through Wikidata.Company names and logos identify the companies in public FDA and registry records and do not imply endorsement.
Lowers the risk of NSAID (nonsteroidal anti-inflammatory drugs, including…. Sold as Cytotec. Every FDA application for this active ingredient: 1 branded and 4 generic.
As of Nov 14, 2026, FDA lists 5 applications for Misoprostol (sold as Cytotec), first approved Dec 27, 1988, with 0 new uses approved and 0 published complete response letters.
First approved: Dec 27, 1988
Applications: 5
New uses approved: 0
Complete response letters: 0
Medicare spending, 2025: $3.4M
Medicare Spending
CMS Part D and Part B, 2025, before manufacturer rebates; matched by generic name
Misoprostol
Part D
$3.4M
-6%
50,127
Cytotec
Part D
$21K
-23%
0
What Pharmacies Pay
Median price per unit across package codes in CMS's weekly NADAC survey, Nov 11, 2026, before rebates; see every drug's price change
MISOPROSTOL 100 MCG TABLET: $0.461 per unitGeneric · -3% in a year
MISOPROSTOL 200 MCG TABLET: $0.689 per unitGeneric · +8% in a year
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient.Drugs@FDA
Pfizer