Levetiracetam

Treats partial-onset seizures. Sold as Keppra, Keppra Xr, Levetiracetam In Sodium Chloride, Elepsia Xr, Spritam. Every FDA application for this active ingredient: 7 branded and 106 generic.

As of Nov 15, 2026, FDA lists 113 applications for Levetiracetam (sold as Keppra, Keppra Xr, Levetiracetam In Sodium Chloride and others), first approved Nov 30, 1999, with 18 new uses approved and 3 published complete response letters.

• First approved: Nov 30, 1999
• Applications: 113
• New uses approved: 18
• Complete response letters: 3
• Medicare spending, 2025: $264M
• First approved in the EU: Sep 29, 2000
• First approved in Japan: Jul 23, 2010