Logos are each company's own site icon, matched by name through Wikidata.Company names and logos identify the companies in public FDA and registry records and do not imply endorsement.
Treats moderate to severe vasomotor symptoms due to menopause. Sold as Combipatch, Activella. Every FDA application for this active ingredient: 4 branded and 8 generic.
As of Nov 15, 2026, FDA lists 12 applications for Estradiol; Norethindrone Acetate (sold as Combipatch, Activella), first approved Aug 7, 1998, with 1 new use approved and 0 published complete response letters.
First approved: Aug 7, 1998
Applications: 12
New uses approved: 1
Complete response letters: 0
What Pharmacies Pay
Median price per unit across package codes in CMS's weekly NADAC survey, Nov 11, 2026, before rebates; see every drug's price change
COMBIPATCH 0.05-0.14 MG PTCH: $31.81 per unitBrand · +2% in a year
COMBIPATCH 0.05-0.25 MG PTCH: $31.79 per unitBrand · +2% in a year
Clinical Trials
12 open or ongoing studies name this ingredient as an intervention, including as a comparator; newest first. See all
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient.Drugs@FDA
Novo Nordisk
Lupin