Sold as Desogen, Ortho-Cept, Mircette, Cyclessa. Every FDA application for this active ingredient: 4 branded and 24 generic.
As of Nov 15, 2026, FDA lists 28 applications for Desogestrel; Ethinyl Estradiol (sold as Desogen, Ortho-Cept, Mircette and others), first approved Dec 10, 1992, with 0 new uses approved and 0 published complete response letters.
| Apri | Part D | $147K | +9% | 1,459 |
| Isibloom | Part D | $119K | +2% | 1,338 |
| Enskyce | Part D | $78K | -4% | 811 |
| Velivet | Part D | $31K | -7% | 128 |
| Juleber | Part D | $19K | +107% | 200 |
| Reclipsen | Part D | $6K | -17% | 58 |
| Cyred Eq | Part D | $2K | +100% | 13 |
| Combined Oral Contraceptive Pill and Resistance StarchMetabolic Syndrome, Polycystic Ovary Syndrome · University of Pennsylvania | Phase 2 | Recruiting | Feb 28, 2025 |
| Oral Contraceptive Pill (OCP) PharmacogenomicsContraception, Pharmacogenomic Drug Interaction · Yale University | Phase 4 | Recruiting | Mar 28, 2024 |
| Assessing the Impact of Contraceptives on Bone Health Using 41CaOther Disorders of Bone Development and Growth · Penn State University | Phase 4 | Active, not recruiting | Feb 20, 2015 |
| Dec 10, 1992 | DesogenNDA 20071 · New molecular entity, new combination | Organon USA Inc | 20 | Discontinued |
| Dec 14, 1992 | Ortho-CeptNDA 20301 · New formulation or manufacturer | Janssen Pharms | 23 | Discontinued |
| Apr 22, 1998 | MircetteNDA 20713 · New dosage form | Teva Branded Pharm | 11 | Discontinued |
| Aug 12, 1999 | Desogestrel And Ethinyl EstradiolANDA 75256 | Duramed Pharms Barr | 13 | Marketed |
| Dec 20, 2000 | CyclessaNDA 21090 · New dosage form | Aspen Global Inc | 7 | Marketed |
| Apr 5, 2002 | KarivaANDA 75863 | Barr | 9 | Marketed |
| Feb 24, 2004 | Velivet, Desogestrel; EthinylANDA 76455 | Duramed Pharms Barr | 1 | Marketed |
| Jul 29, 2005 | Desogestrel And Ethinyl EstradiolANDA 76915 | Watson Labs | 5 | Marketed |
| Jan 24, 2006 | Desogestrel And Ethinyl Estradiol, Desogestrel; Ethinyl EstradiolANDA 77182 | Dr Reddys Labs SA | 3 | Marketed |
| Dec 29, 2008 | Desogestrel And Ethinyl EstradiolANDA 76916 | Dr Reddys Labs SA | 4 | Discontinued |
| Feb 25, 2011 | EmoquetteANDA 76675 | Ph Health | 6 | Discontinued |
| Apr 2, 2012 | VioreleANDA 91346 | Glenmark Pharms Ltd | 7 | Marketed |
| Mar 7, 2013 | EnskyceANDA 201887 | Lupin Ltd | 9 | Marketed |
| Jul 12, 2013 | Desogestrel And Ethinyl EstradiolANDA 91234 | Novast Labs | 4 | Marketed |
| Aug 1, 2013 | PimtreaANDA 91247 | Novast Labs | 5 | Marketed |
| Aug 30, 2013 | Desogestrel And Ethinyl EstradiolANDA 202296 | Xiromed | 4 | Marketed |
| Apr 30, 2015 | KimidessANDA 76681 | Ph Health | 2 | Discontinued |
| May 20, 2015 | Desogestrel And Ethinyl EstradiolANDA 202085 | Xiromed | 3 | Discontinued |
| Aug 12, 2015 | BekyreeANDA 202226 | Lupin | 6 | Marketed |
| Aug 12, 2015 | IsibloomANDA 202789 | Xiromed | 3 | Marketed |
| Sep 9, 2016 | VolneaANDA 202689 | Xiromed | 3 | Marketed |
| Mar 22, 2017 | SimliyaANDA 206853 | Aurobindo Pharma | 5 | Marketed |
| May 17, 2017 | KalligaANDA 207081 | Aurobindo Pharma | 2 | Marketed |
| Jun 5, 2017 | Desogestrel And Ethinyl EstradiolANDA 209170 | Naari Pte | 0 | Marketed |
| Sep 13, 2018 | Desogestrel And Ethinyl EstradiolANDA 207067 | Naari Pte | 1 | Marketed |
| May 2, 2025 | AveriANDA 218933 | Avion Pharms | 0 | Marketed |
| Mar 18, 2026 | Desogestrel And Ethinyl EstradiolANDA 219761 | Annora Pharma | 0 | Marketed |
| Jul 7, 2026 | Desogestrel And Ethinyl EstradiolANDA 219670 | Annora Pharma | 0 | Marketed |
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA
Lupin
Aurobindo Pharma