Clindamycin Phosphate

Treats serious infections caused by susceptible anaerobic bacteria. Sold as Cleocin Phosphate, Cleocin T, Cleocin, Clindamycin Phosphate In Dextrose 5%, Cleocin Phosphate In Dextrose 5% In Plastic Container and 6 more. Every FDA application for this active ingredient: 15 branded and 76 generic.

As of Nov 15, 2026, FDA lists 91 applications for Clindamycin Phosphate (sold as Cleocin Phosphate, Cleocin T, Cleocin and others), first approved Oct 2, 1972, with 2 new uses approved and 0 published complete response letters.

First approved: Oct 2, 1972
Applications: 91
New uses approved: 2
Complete response letters: 0
Medicare spending, 2025: $29.1M
Shortage: Current

Medicare Spending

CMS Part D and Part B, 2025, before manufacturer rebates; matched by generic name


Clindamycin Phosphate	Part D	$28.9M	+11%	366,798
Cleocin	Part D	$129K	+8%	338
Clindesse	Part D	$38K	-33%	132
Xaciato	Part D	$24K	+72%	108
Clindagel	Part D	$19K	-73%	0
Clindacin P	Part D	$11K	-52%	52
Cleocin Phosphate	Part B	$10K	-86%	2,978
Clindacin	Part D	$9K	-60%	19
Cleocin Phosphate	Part D	$8K	-10%	72
Cleocin T	Part D	$7K	+1%	20
Clindacin Etz	Part D	$6K	+154%	71

What Pharmacies Pay

Median price per unit across package codes in CMS's weekly NADAC survey, Nov 11, 2026, before rebates; see every drug's price change

CLINDAMYCIN (PEDI) 75 MG/5 ML: $0.133 per MLGeneric · -19% in a year
CLINDAMYCIN 2% VAGINAL CREAM: $1.87 per GMGeneric · +19% in a year
CLINDAMYCIN HCL 150 MG CAPSULE: $0.105 per unitGeneric · -2% in a year
CLINDAMYCIN HCL 300 MG CAPSULE: $0.179 per unitGeneric · -2% in a year
CLINDAMYCIN HCL 75 MG CAPSULE: $0.269 per unitGeneric · -11% in a year
CLINDAMYCIN PHOSPHATE 1% FOAM: $1.97 per GMGeneric · -36% in a year
CLINDAMYCIN PHOSPHATE 1% GEL: $3.63 per MLGeneric · -55% in a year
CLEOCIN 100 MG VAGINAL OVULE: $60.24 per unitBrand · +3% in a year
CLEOCIN 2% VAGINAL CREAM: $1.79 per GMBrand · +2% in a year
CLINDESSE 2% VAGINAL CREAM: $26.60 per GMBrand · 0% in a year
XACIATO 2% VAGINAL GEL: $18.89 per GMBrand · +5% in a year

Orphan Designations (FDA)

3 designations, 0 approved for the designated use; see all orphan designations

Treatment of sarcoidosisAutoimmunity Research Foundation · designated Aug 9, 2006
Treatment of Pneumocystis carinii pneumonia associated with AIDS patients.Pharmacia & Upjohn · designated Oct 28, 1988
Prevention of Pneumocystis carinii pneumonia in AIDS patients.Pfizer Inc. · designated Oct 28, 1988

Approvals in Japan (PMDA)

PMDA's English list since 2008, matched by ingredient; see all Japanese approvals

Dalacin SDrugs with a new additional indication for cellulitis around the jaw bone and jaw inflammation. · Pfizer Japan Inc. · Feb 21, 2014

Shortages

FDA's drug shortage list, as of Nov 13, 2026

Shortage	Status	First posted	Updated
Clindamycin Phosphate Injection	Current	Mar 21, 2023	Nov 9, 2026

Clinical Trials

60 open or ongoing studies name this ingredient as an intervention, including as a comparator; newest first. See all


Safety, Tolerability, and Clinical Effectiveness of Adapalene/Clindamycin Phosphate Gel (Klenzit®-C) in Vietnamese Patients With Mild to Moderate Acne VulgarisAcne · IR INNOVATE RESEARCH PRIVATE LIMITED	Phase 4	Recruiting	Nov 5, 2026
Is Routine Dental Clearance or Antibiotic Prophylaxis Before Dental Procedures Necessary in Total Joint Arthroplasty?Elective Primary THA or TKA · Creighton University	Not applicable	Not yet recruiting	Nov 4, 2026
Comparing Nadifloxacin Plus Tretinoin Versus Clindamycin Plus Tretinoin Creams for Mild-to-Moderate AcneAcne Vulgaris · Nishtar Medical University	Phase 4	Recruiting	Nov 4, 2026
Comparison of Amoxicillin, Clindamycin and Azithromycin Single Doses Antibiotic Prophylaxis in Patient Undergoing Lower Third Molar ExtractionWisdom Tooth Removal, Antibiotic Prophylaxis · Dow University of Health Sciences	Phase 4	Recruiting	Oct 26, 2026
Prevention of Vaginal Cuff Infection After Hysterectomy by Addition of Vaginal ClindamycinSurgical Site Infection, Vaginal Cuff Cellulitis · Baylor Research Institute	—	Enrolling by invitation	Oct 22, 2026
Clascoterone Versus Clindamycin Added to Adapalene/Benzoyl Peroxide for Moderate Facial AcneAcne Vulgaris · Allied Hospital Faisalabad	Phase 4	Not yet recruiting	Oct 19, 2026
Moxifloxacin Versus Clindamycin in the Management of Odontogenic Maxillofacial Infectious ProcessesOdontogenic Infection, Maxillofacial Infection · Nishtar Medical University	Not applicable	Not yet recruiting	Sep 9, 2026
A Randomized, Multicenter, Open-label, Active-controlled Phase Ib Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Multiple Intravaginal Doses of GenSci142 in Patients With Bacterial Vaginosis (BV)Randomized, Open-label · Changchun GeneScience Pharmaceutical Co., Ltd.	Phase 1	Recruiting	Jun 23, 2026

Applications

NDAs, BLAs and generic ANDAs for this ingredient, oldest first; each opens its full history


Oct 2, 1972	Cleocin PhosphateNDA 50441	Pfizer	35	Marketed
Jul 9, 1980	Cleocin T, CleocinNDA 50537 · New dosage form	Pfizer	28	Discontinued
Feb 8, 1982	Cleocin TANDA 62363	Pharmacia And Upjohn	2	Discontinued
Jan 7, 1987	Cleocin TNDA 50615 · New dosage form	Pfizer	10	Marketed
Jul 24, 1987	Clindamycin PhosphateANDA 62800	Almaject	18	Discontinued
Jul 24, 1987	Clindamycin PhosphateANDA 62801	Almaject	22	Discontinued
Oct 15, 1987	Clindamycin PhosphateANDA 62806	Hikma	7	Discontinued
Oct 16, 1987	Cleocin PhosphateANDA 62803	Pfizer	15	Marketed
Apr 21, 1988	Clindamycin PhosphateANDA 62953	Hikma	5	Discontinued
Apr 25, 1988	Clindamycin PhosphateANDA 62889	Hikma	7	Marketed
May 9, 1988	Clindamycin PhosphateANDA 62905	Loch	3	Discontinued
Sep 1, 1988	Clindamycin PhosphateANDA 62811	G And W Labs Inc	13	Discontinued
Sep 29, 1988	Clindamycin PhosphateANDA 62943	Almaject	17	Discontinued
Oct 20, 1988	Clindamycin PhosphateANDA 62913	Marsam Pharms LLC	1	Discontinued
Jan 11, 1989	Clindamycin PhosphateANDA 62944	Boca Pharma LLC	6	Discontinued
May 31, 1989	Cleocin TNDA 50600 · New dosage form	Pfizer	12	Marketed
Jun 28, 1989	Clindamycin PhosphateANDA 62930	Vintage Pharms	8	Discontinued
Aug 28, 1989	Clindamycin PhosphateANDA 63068	Hikma	6	Discontinued
Aug 30, 1989	Cleocin Phosphate In Dextrose 5% In Plastic ContainerNDA 50639 · New dosage form	Pfizer	35	Discontinued
Dec 22, 1989	Clindamycin Phosphate In Dextrose 5%NDA 50635 · New dosage form	Abraxis Pharm	0	Marketed
Dec 22, 1989	Clindamycin Phosphate In Dextrose 5%NDA 50636 · New dosage form	Abraxis Pharm	0	Discontinued
Dec 29, 1989	Clindamycin Phosphate In Dextrose 5% In Plastic ContainerNDA 50648 · New dosage form	Baxter Hlthcare	0	Discontinued
Dec 29, 1989	Clindamycin PhosphateANDA 63041	Teva Parenteral	10	Discontinued
May 29, 1992	Clindamycin PhosphateANDA 63282	Teva Parenteral	2	Discontinued
Aug 11, 1992	CleocinNDA 50680 · New dosage form	Pfizer	11	Marketed
Sep 30, 1992	Clinda-DermANDA 63329	Padagis US	6	Discontinued
Nov 30, 1995	Clindamycin PhosphateANDA 64050	Padagis US	9	Marketed
Sep 27, 1996	Clindamycin PhosphateANDA 64108	Ingenus Pharms LLC	0	Discontinued
Sep 30, 1996	ClindetsANDA 64136	Perrigo Co	6	Discontinued
Jun 5, 1997	Clindamycin PhosphateANDA 64159	Fougera Pharms Inc	8	Marketed
Jul 15, 1997	Clindamycin PhosphateANDA 63304	Xttrium Labs Inc	3	Discontinued
Aug 13, 1999	CleocinNDA 50767 · New dosage form	Pfizer	10	Marketed
Jan 28, 2000	Clindamycin PhosphateANDA 64160	Fougera Pharms	10	Marketed
May 25, 2000	Clindamycin PhosphateANDA 65049	Padagis US	11	Marketed
Nov 27, 2000	ClindagelNDA 50782 · New dosage form	Bausch	0	Marketed
Jun 29, 2001	Clindamycin Phosphate In Dextrose 5% In Plastic ContainerANDA 65027	Abbott Labs	2	Discontinued
Jan 31, 2002	Clindamycin PhosphateANDA 65067	Fougera Pharms	9	Marketed
Mar 31, 2004	Clindamycin PhosphateANDA 65184	Taro Pharm Inds	3	Marketed
Sep 24, 2004	Clindamycin PhosphateANDA 65206	Hikma	3	Marketed
Oct 22, 2004	EvoclinNDA 50801 · New dosage form	Quagen	5	Discontinued
Nov 30, 2004	ClindesseNDA 50793 · New formulation or manufacturer	Padagis US	10	Marketed
Dec 27, 2004	Clindamycin PhosphateANDA 65139	Fougera Pharms	4	Marketed
Feb 14, 2006	Clindamycin PhosphateANDA 65254	Fougera Pharms	2	Discontinued
Mar 29, 2007	Clindamycin PhosphateANDA 65346	Fresenius Kabi USA	0	Discontinued
May 9, 2007	Clindamycin PhosphateANDA 65347	Fresenius Kabi USA	0	Discontinued
Mar 31, 2010	Clindamycin PhosphateANDA 90785	Padagis Israel	2	Marketed
Jun 17, 2010	Clindamycin PhosphateANDA 65513	Epic Pharma LLC	1	Marketed
Sep 30, 2011	Clindamycin PhosphateANDA 90108	Sagent Pharms Inc	9	Marketed
Sep 30, 2011	Clindamycin PhosphateANDA 90109	Sagent Pharms Inc	10	Marketed
May 31, 2012	Clindamycin Phosphate In 5% Dextrose In Plastic ContainerANDA 201692	Sandoz Inc	9	Marketed
Apr 4, 2013	Clindamycin Phosphate In 5% Dextrose In Plastic ContainerANDA 203048	Rising	5	Marketed
May 29, 2015	Clindamycin PhosphateANDA 203343	Ph Health	2	Discontinued
Dec 30, 2016	Clindamycin PhosphateANDA 206945	Pai Holdings Pharm	3	Discontinued
Apr 20, 2017	Clindamycin Phosphate In 0.9% Sodium ChlorideNDA 208083 · New formulation or manufacturer	Baxter Hlthcare Corp	6	Marketed
Jun 28, 2017	Clindamycin Phosphate In 5% Dextrose In Plastic ContainerANDA 208084	Baxter Hlthcare Corp	3	Marketed
Oct 10, 2017	Clindamycin PhosphateANDA 204749	Rising	4	Discontinued
Oct 10, 2017	Clindamycin PhosphateANDA 204748	Rising	4	Discontinued
Feb 8, 2018	Clindamycin PhosphateANDA 209846	Chartwell Rx	2	Marketed
Jul 16, 2018	Clindamycin PhosphateANDA 208767	Zydus Lifesciences	2	Marketed
Jan 28, 2019	Clindamycin PhosphateANDA 209914	Encube Ethicals	3	Marketed
Mar 11, 2020	Clindamycin PhosphateANDA 210004	Taro	0	Marketed
Jul 29, 2020	Clindamycin PhosphateANDA 211872	Amvika	0	Marketed
Nov 10, 2020	Clindamycin PhosphateANDA 214052	Sun Pharma Canada	0	Marketed
Dec 31, 2020	Clindamycin PhosphateANDA 212104	Padagis Israel	0	Marketed
Feb 10, 2021	Clindamycin PhosphateANDA 214251	Glenmark Pharms Ltd	0	Marketed
Mar 8, 2021	Clindamycin PhosphateANDA 214604	Padagis Israel	0	Marketed
Mar 11, 2021	Clindamycin PhosphateANDA 212438	Encube	1	Marketed
Jun 28, 2021	Clindamycin PhosphateANDA 214526	Sun Pharma Canada	0	Marketed
Aug 13, 2021	Clindamycin PhosphateANDA 212842	Solaris Pharma Corp	0	Marketed
Sep 20, 2021	Clindamycin PhosphateANDA 210778	Glenmark Pharms Ltd	0	Marketed
Dec 7, 2021	XaciatoNDA 215650 · New formulation or manufacturer	Organon LLC	1	Marketed
Jan 18, 2022	Clindamycin PhosphateANDA 215607	Encube	0	Marketed
Aug 5, 2022	Clindamycin PhosphateANDA 214668	Amneal	0	Marketed
Nov 3, 2022	Clindamycin PhosphateANDA 215219	Amneal	0	Discontinued
Apr 5, 2023	Clindamycin Phosphate In Dextrose 5%ANDA 214401	Hikma	0	Marketed
Sep 19, 2023	Clindamycin PhosphateANDA 216587	Zydus Lifesciences	0	Marketed
Apr 2, 2024	Clindamycin PhosphateANDA 212466	Alembic	0	Marketed
Jun 13, 2025	Clindamycin PhosphateANDA 219612	Carnegie	0	Marketed
Mar 18, 2026	Clindamycin PhosphateANDA 218942	Aurobindo Pharma Ltd	0	Marketed
Mar 23, 2026	Clindamycin PhosphateANDA 218300	Rising	0	Marketed
—	Cleocin PhosphateANDA 61839	Pharmacia And Upjohn	0	Discontinued
—	Clindamycin PhosphateANDA 62747	Abraxis Pharm	0	Discontinued
—	Clindamycin PhosphateANDA 62795	Quad Pharms	0	Discontinued
—	Clindamycin PhosphateANDA 62819	Solopak	0	Discontinued
—	Clindamycin PhosphateANDA 62852	Solopak	0	Discontinued
—	Clindamycin PhosphateANDA 62877	Quad Pharms	0	Discontinued
—	Clindamycin PhosphateANDA 62900	Watson Labs	0	Discontinued
—	Clindamycin PhosphateANDA 62908	Bristol Myers Squibb	0	Discontinued
—	Clindamycin PhosphateANDA 62928	Igi Labs Inc	0	Discontinued
—	Clindamycin PhosphateANDA 63079	Watson Labs	0	Discontinued
—	Clindamycin PhosphateANDA 63163	Bedford	0	Discontinued

Show all 91

Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA