Sold as Diuril. Every FDA application for this active ingredient: 1 branded and 6 generic.
As of Nov 15, 2026, FDA lists 7 applications for Chlorothiazide Sodium (sold as Diuril), first approved Sep 4, 1958, with 0 new uses approved and 0 published complete response letters.
| Product | Part | Spending, 2025 | Change | Beneficiaries |
|---|---|---|---|---|
| Chlorothiazide Sodium | Part B | $14K | -34% | 116 |
| SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive TherapyHypertension · Ottawa Hospital Research Institute | Phase 4 | Not yet recruiting | Jul 7, 2026 |
| TACTIC-HF: Sequential Diuretic Strategies in Ambulatory Worsening Heart FailureAcute Heart Failure (AHF) · Lucrecia Maria Burgos | Phase 4 | Not yet recruiting | May 18, 2026 |
| Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite AthletesSafety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes · Enhanced Emirates Limited | Not applicable | Enrolling by invitation | May 6, 2026 |
| POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart FailureAcute Heart Failure (AHF), Congestive Heart Failure Acute · Hospital de Clinicas de Porto Alegre | Phase 2 / Phase 3 | Not yet recruiting | Mar 13, 2026 |
| Triple Antihypertensive Medication After Intracerebral Hemorrhage for Blood Pressure ControlIntracerebral Hemorrhage · The University of Hong Kong | Not applicable | Recruiting | Mar 9, 2026 |
| Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis PatientsHypertension, Peritoneal Dialysis · Chinese University of Hong Kong | Phase 4 | Recruiting | Dec 9, 2025 |
| The Role of Skin Sodium Accumulation in Chronic Kidney DiseaseChronic Kidney Diseases · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Not applicable | Recruiting | Jun 13, 2025 |
| Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone PreventionKidney Stone · Insel Gruppe AG, University Hospital Bern | Phase 2 | Recruiting | Nov 1, 2023 |
| Sep 4, 1958 | DiurilNDA 11145 · New molecular entity | Rising | 57 | Discontinued |
| Oct 16, 2009 | Chlorothiazide SodiumANDA 90896 | Fresenius Kabi USA | 0 | Marketed |
| Jul 26, 2011 | Chlorothiazide SodiumANDA 91546 | Sun Pharm | 0 | Marketed |
| Apr 22, 2013 | Chlorothiazide SodiumANDA 202561 | Am Regent | 0 | Marketed |
| Jun 18, 2014 | Chlorothiazide SodiumANDA 202493 | Rk Pharma | 0 | Discontinued |
| May 29, 2015 | Chlorothiazide SodiumANDA 202462 | Sagent Pharms Inc | 0 | Marketed |
| Oct 3, 2024 | Chlorothiazide SodiumANDA 218630 | Gland | 0 | Marketed |
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA
Fresenius Kabi USA