Tools / Drug approvals and letters / Drugs Carbon Dioxide Sold as Carbon Dioxide, Usp, Carbon Dioxide, USP. Every FDA application for this active ingredient.
As of Nov 15, 2026, FDA lists 17 applications for Carbon Dioxide (sold as Carbon Dioxide, Usp, Carbon Dioxide, USP), first approved Jul 5, 2013, with 0 new uses approved and 0 published complete response letters.
First approved : Jul 5, 2013 Applications : 17 New uses approved : 0 Complete response letters : 0 Clinical Trials 310 open or ongoing studies name this ingredient as an intervention, including as a comparator; newest first. See all Study Phase Status Posted Evaluation of the Efficacy and Safety of High-Flow Oxygen Therapy Compared With a Nasal Positive Airway Pressure (nPAP) Mask Using Transcutaneous Capnometry During Endoscopic Procedures in High-Risk Patients Sedation Complication, Colonoscopy (Procedure) · University of Ulm Not applicable Enrolling by invitation Nov 12, 2026 Efficacy of Fractional Co2 Laser With Topical Tacrolimus 0.1 in the Treatment of Nail Psoriasis Nail Psoriasis · Cairo University Not applicable Not yet recruiting Nov 5, 2026 Evaluation of the Efficacy and Safety of Fractional CO₂ Laser With and Without Intradermal Botulinum Toxin A in the Treatment of Inflammatory Facial Acne Vulgaris. Acne, Acne Papulopustulosa · Cairo University Phase 3 Not yet recruiting Nov 5, 2026 Preoperative Frailty and Suboptimal Mask Ventilation in Cardiac Surgery Patients Frailty, Suboptimal Mask Ventilation · Ankara City Hospital Bilkent — Not yet recruiting Nov 4, 2026 Fluid Responsiveness in Laparoscopic Surgery: End-Expiratory Occlusion Test Versus Mini-Fluid Challenge Fluid Responsiveness, Laparoscopic Surgery · University Of Perugia — Not yet recruiting Nov 2, 2026 Low Pneumoperitoneum Pressure for Delirium Prevention in Elderly Laparoscopy Postoperative Delirium (POD), Intracranial Hypertension · Benha University Not applicable Recruiting Oct 30, 2026 Ultraformer MPT Combined With Fractional CO2 Versus Fractional CO2 Alone for Facial Rejuvenation Skin Aging · Clinique Face MD Not applicable Recruiting Oct 27, 2026 The Hemodynamic Impact of High-frequency Oscillatory Ventilation and Periodic Sighs in Preterm Infants Preterm, Respiratory Distress Syndrome in Premature Infant · Alexandria University Not applicable Not yet recruiting Oct 27, 2026
Applications NDAs, BLAs and generic ANDAs for this ingredient, oldest first; each opens its full history Approved Application Sponsor Supplements Marketing Jul 5, 2013 Carbon Dioxide, Usp NDA 205764 · MEDGAS 0 Marketed Jul 5, 2013 Carbon Dioxide, Usp NDA 205815 · MEDGAS 0 Marketed Jul 20, 2013 Carbon Dioxide, Usp NDA 205846 · MEDGAS 0 Marketed Jul 21, 2013 Carbon Dioxide, Usp NDA 205852 · MEDGAS 0 Marketed Sep 7, 2013 Carbon Dioxide, Usp NDA 206025 · MEDGAS 0 Marketed May 25, 2014 Carbon Dioxide, Usp NDA 207166 · MEDGAS 0 Marketed Aug 22, 2017 Carbon Dioxide, Usp NDA 210816 · MEDGAS 0 Marketed Jun 15, 2019 Carbon Dioxide, Usp NDA 213507 · MEDGAS 0 Marketed Oct 18, 2021 Carbon Dioxide, Usp NDA 216614 0 Marketed Feb 25, 2022 Carbon Dioxide, Usp NDA 217082 0 Marketed Apr 26, 2022 Carbon Dioxide, Usp NDA 217332 0 Marketed Feb 17, 2024 Carbon Dioxide, Usp NDA 219303 0 Marketed Aug 10, 2024 Carbon Dioxide, Usp NDA 219779 0 Marketed Feb 2, 2025 Carbon Dioxide, USP NDA 220266 · MEDGAS 0 Marketed Apr 21, 2025 Carbon Dioxide, Usp NDA 220461 0 Marketed Jun 16, 2025 Carbon Dioxide, Usp NDA 220634 0 Marketed Oct 25, 2025 Carbon Dioxide, Usp NDA 221021 0 Marketed
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA
