Atenolol

Treats hypertension. Sold as Tenormin. Every FDA application for this active ingredient: 2 branded and 30 generic.

As of Nov 15, 2026, FDA lists 32 applications for Atenolol (sold as Tenormin), first approved Aug 19, 1981, with 3 new uses approved and 0 published complete response letters.

First approved: Aug 19, 1981
Applications: 32
New uses approved: 3
Complete response letters: 0
Medicare spending, 2025: $48.9M

Medicare Spending

CMS Part D and Part B, 2025, before manufacturer rebates; matched by generic name


Atenolol	Part D	$46.4M	-7%	1,484,560
Tenormin	Part D	$2.5M	-18%	527

What Pharmacies Pay

Median price per unit across package codes in CMS's weekly NADAC survey, Nov 11, 2026, before rebates; see every drug's price change

ATENOLOL 100 MG TABLET: $0.037 per unitGeneric · -17% in a year
ATENOLOL 25 MG TABLET: $0.022 per unitGeneric · -5% in a year
ATENOLOL 50 MG TABLET: $0.023 per unitGeneric · -8% in a year
TENORMIN 50 MG TABLET: $12.78 per unitBrand · new this year

Clinical Trials

9 open or ongoing studies name this ingredient as an intervention, including as a comparator; newest first. See all


Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular ComplexesPremature Ventricular Complexes, Premature Ventricular Contraction (PVC) · Western Sydney Local Health District	Not applicable	Recruiting	Mar 3, 2026
MEdical Treatment in Idiopathic Ventricular Fibrillation PatientsIdiopathic Ventricular Fibrillation, Cardiac Arrest, Out-Of-Hospital · Bo Gregers Winkel	Phase 4	Recruiting	Feb 12, 2026
Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF)Heart Failure, HFpEF · Weill Medical College of Cornell University	Phase 4	Enrolling by invitation	Dec 23, 2025
Heart Rate Control Before Cardiac Computed Tomography in Adults for the Evaluation of Coronary Artery DiseaseCoronary Arterial Disease (CAD), Ischemic Heart Disease (IHD) · Gødstrup Hospital	Phase 2 / Phase 3	Enrolling by invitation	Dec 5, 2025
Stroke Minimization Through Additive Anti-atherosclerotic Agents in Routine Treatment II Study (SMAART II)Stroke, Medication Adherence · Northern California Institute of Research and Education	Phase 3	Recruiting	Jul 27, 2023
A Preliminary Study for INFORMEDHeart Failure, Heart Failure, Diastolic · Weill Medical College of Cornell University	Phase 4	Recruiting	Oct 18, 2022
Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal SurgeriesHypotension Drug-Induced · Damanhour Teaching Hospital	Phase 4	Recruiting	Jun 4, 2021
Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early PregnancySystolic Hypertension, Pregnancy Related · Marshall University	—	Recruiting	Feb 16, 2021

Applications

NDAs, BLAs and generic ANDAs for this ingredient, oldest first; each opens its full history


Aug 19, 1981	TenorminNDA 18240 · New molecular entity	Twi Pharms	36	Marketed
Jul 15, 1988	AtenololANDA 72304	Aiping Pharm Inc	22	Marketed
Sep 13, 1989	TenorminNDA 19058 · New dosage form	Astrazeneca	16	Discontinued
Sep 17, 1991	AtenololANDA 73026	Pharmobedient	33	Marketed
Dec 19, 1991	AtenololANDA 73543	Novitium Pharma	19	Discontinued
Dec 19, 1991	AtenololANDA 73542	Novitium Pharma	19	Discontinued
Dec 27, 1991	AtenololANDA 73353	Watson Labs Teva	17	Discontinued
Dec 27, 1991	AtenololANDA 73352	Watson Labs	17	Discontinued
Jan 24, 1992	AtenololANDA 73457	Mylan	25	Marketed
Apr 28, 1992	AtenololANDA 74099	Novitium Pharma	20	Discontinued
Oct 30, 1992	AtenololANDA 73676	Scs	0	Discontinued
Mar 30, 1993	AtenololANDA 73476	Sun Pharm Industries	18	Discontinued
Mar 30, 1993	AtenololANDA 73475	Sun Pharm Industries	18	Discontinued
May 28, 1993	AtenololANDA 73316	Teva	6	Discontinued
May 28, 1993	AtenololANDA 73315	Teva	6	Discontinued
Feb 28, 1994	AtenololANDA 74265	Chartwell Rx	15	Discontinued
Mar 23, 1994	AtenololANDA 74126	Mylan	9	Discontinued
Jan 18, 1995	AtenololANDA 74056	Teva	24	Marketed
Feb 21, 1995	AtenololANDA 74127	Nostrum Labs	0	Discontinued
Feb 24, 1995	AtenololANDA 74120	Teva Pharms	3	Discontinued
Jul 17, 1997	AtenololANDA 74101	Pliva	2	Discontinued
Jul 30, 1997	AtenololANDA 74499	Sun Pharm Industries	13	Discontinued
Jul 30, 2004	AtenololANDA 76907	Able	0	Discontinued
Jan 28, 2005	AtenololANDA 76900	Zydus Pharms USA	12	Marketed
Sep 13, 2006	AtenololANDA 77443	Unique	4	Marketed
Dec 27, 2006	AtenololANDA 77877	Ipca Labs Ltd	5	Marketed
Jul 10, 2007	AtenololANDA 78210	Sun Pharm Inds Inc	1	Discontinued
Oct 31, 2007	AtenololANDA 78512	Aurobindo Pharma	5	Marketed
Sep 25, 2009	AtenololANDA 78254	Northstar Hlthcare	3	Discontinued
Nov 21, 2019	AtenololANDA 213136	Unichem	1	Marketed
—	AtenololANDA 73318	Apothecon	0	Discontinued
—	AtenololANDA 73317	Apothecon	0	Discontinued

Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA