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Treats acne. Sold as Differin. Every FDA application for this active ingredient: 5 branded and 11 generic.
As of Nov 14, 2026, FDA lists 16 applications for Adapalene (sold as Differin), first approved May 31, 1996, with 1 new use approved and 0 published complete response letters.
First approved: May 31, 1996
Applications: 16
New uses approved: 1
Complete response letters: 0
Medicare spending, 2025: $4.4M
First approved in Japan: Jul 16, 2008
Medicare Spending
CMS Part D and Part B, 2025, before manufacturer rebates; matched by generic name
Adapalene
Part D
$4.4M
+68%
4,660
Differin
Part D
$0K
-100%
0
What Pharmacies Pay
Median price per unit across package codes in CMS's weekly NADAC survey, Nov 11, 2026, before rebates; see every drug's price change
ADAPALENE 0.1% CREAM: $2.72 per GMGeneric · +10% in a year
ADAPALENE 0.3% GEL: $0.499 per GMGeneric · -9% in a year
ADAPALENE 0.3% GEL PUMP: $0.927 per GMGeneric · -5% in a year
Approvals in Japan (PMDA)
First approved in Japan 145 months after the US. PMDA's English list since 2008, matched by ingredient; see all Japanese approvals
Differin, new ingredientA drug containing a new active ingredient indicated for the treatment of acne vulgaris. · Galderma S.A. · Jul 16, 2008
Clinical Trials
15 open or ongoing studies name this ingredient as an intervention, including as a comparator; newest first. See all
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient.Drugs@FDA
Sun Pharma Canada
Alembic