Sold as Compazine. Every FDA application for this active ingredient: 1 branded and 3 generic.
As of Nov 13, 2026, FDA lists 4 applications for Prochlorperazine (sold as Compazine), first approved Jan 26, 1959, with 0 new uses approved and 0 published complete response letters.
| Prochlorperazine Maleate | Part D | $9.6M | -14% | 435,787 |
| Compro | Part D | $1.1M | -10% | 6,168 |
| Prochlorperazine | Part D | $464K | +14% | 3,205 |
| Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of MigrainesMigraine · Wake Forest University Health Sciences | Phase 3 | Recruiting | Apr 1, 2025 |
| Conventionally Fractionated vs. Hypofractionated Comprehensive Nodal Irradiation for Breast Cancer Using Pencil Beam Scanning Proton TherapyBreast Cancer · Proton Collaborative Group | Phase 3 | Recruiting | May 12, 2023 |
| Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade GliomasGlioblastoma · SignPath Pharma, Inc. | Phase 1 / Phase 2 | Recruiting | Mar 15, 2023 |
| 5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCCSquamous Cell Carcinoma of Head and Neck · Barbara Burtness | Phase 2 | Recruiting | Apr 7, 2022 |
| Jan 26, 1959 | CompazineNDA 11127 · New active ingredient | Glaxosmithkline | 5 | Discontinued |
| Nov 24, 1993 | ProchlorperazineANDA 40058 | Cosette Pharms Nc | 11 | Marketed |
| Jun 28, 2000 | ComproANDA 40246 | Padagis US | 8 | Marketed |
| Jul 11, 2001 | ProchlorperazineANDA 40407 | Able | 1 | Discontinued |
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA
Glaxosmithkline