Sold as Nitrous Oxide, Usp. Every FDA application for this active ingredient.
As of Nov 13, 2026, FDA lists 7 applications for Nitrous Oxide (sold as Nitrous Oxide, Usp), first approved Jun 16, 2013, with 0 new uses approved and 0 published complete response letters.
| Study | Phase | Status | Posted |
|---|---|---|---|
| Medical Nitrous Oxide Combined With Personalized Traumatic Script Exposure for the Treatment of Post-Traumatic Stress DisorderPTSD - Post Traumatic Stress Disorder · University Hospital, Tours | Phase 3 | Not yet recruiting | Nov 10, 2026 |
| Office Hysteroscopy Versus Operating-room Hysteroscopy for Uterine LesionsUterine Polyps, Uterine Fibroids · Nantes University Hospital | Not applicable | Not yet recruiting | Nov 2, 2026 |
| Boyle-Davis Mouth Gag Timing in Pediatric Tonsil SurgeryTonsillectomy and Adenotonsillectomy in Children · Yahyali State Hospital | Not applicable | Not yet recruiting | Oct 22, 2026 |
| Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide MonotherapyDental Anxiety in Children, Child Behaviour · Shaheed Zulfiqar Ali Bhutto Medical University | Not applicable | Recruiting | Oct 15, 2026 |
| Prospective Study To Assess The Outcomes Of Nitrous Oxide Cryoablation For Treatment Of Duodenal Adenomas In Patients With Hereditary Conditions Such As FAP, HNPCCProspective Study , Questionaires, Outcomes · M.D. Anderson Cancer Center | Not applicable | Not yet recruiting | Oct 5, 2026 |
| Cryoneurolysis in Anterior Cruciate Ligament Reconstruction (ACLR)ACL Reconstruction (ACLR) With a Bone-patellar Tendon-bone (BPTB) Autograft · NYU Langone Health | Not applicable | Not yet recruiting | Jul 28, 2026 |
| Psychosocial Support for Nitrous Oxide MisuseBrief Psychosocial Intervention · Queen Mary University of London | Not applicable | Not yet recruiting | Jul 21, 2026 |
| Concentrations of Nitrous Oxide in Blood, Exhaled Air and Urine After Various Types of Exposure.Intoxication by Drug · University of Aarhus | Not applicable | Recruiting | Jul 8, 2026 |
| Approved | Application | Sponsor | Supplements | Marketing |
|---|---|---|---|---|
| Jun 16, 2013 | Nitrous Oxide, UspNDA 205704 · MEDGAS | Air Liquide America Speciality Gases | 0 | Marketed |
| Sep 3, 2013 | Nitrous Oxide, UspNDA 206009 · MEDGAS | Nitrous Oxide Corp | 0 | Marketed |
| Sep 6, 2013 | Nitrous Oxide, UspNDA 206014 · MEDGAS | Nitrous Oxide Of Canada | 0 | Marketed |
| Nov 25, 2014 | Nitrous Oxide, UspNDA 208069 · MEDGAS | Strata Medical Innovations | 0 | Marketed |
| Jan 9, 2017 | Nitrous Oxide, UspNDA 209989 | Matheson Tri-Gas Inc | 0 | Marketed |
| Mar 6, 2017 | Nitrous Oxide, UspNDA 210235 · MEDGAS | Praxair Distribution Inc | 0 | Marketed |
| Aug 9, 2026 | Nitrous Oxide, UspNDA 221892 | Linde Gas Equip | 0 | Marketed |
Applications, approvals and products come from FDA's Drugs@FDA data files, refreshed weekly, grouped by active ingredient as FDA spells it. Complete response letters are FDA's published letters. Medicare spending is CMS's Part D and Part B dashboard, matched to this ingredient by generic name; shortages are FDA's shortage list, matched by application number; clinical trials are ClinicalTrials.gov studies naming the ingredient as an intervention, refreshed daily; safety programs are FDA's REMS list, matched by application number or, for shared programs, by ingredient. Drugs@FDA
